Quetiapine does not have UK marketing authorisation for treating generalised anxiety disorder (GAD) and therefore this use is off-label. Quetiapine is available in generic formulations. Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials Narong Maneeton,1 Benchalak Maneeton,1 Pakapan Woottiluk,2 Surinporn Likhitsathian,1 Sirijit Suttajit,1 Vudhichai Boonyanaruthee,1 Manit Srisurapanont1 1Department of Psychiatry, Faculty of Medicine. In summary, quetiapine can be a useful anxiolytic intervention among persons with schizophrenia, bipolar disorder, refractory depression with comorbid anxiety, and treatment-resistant generalized anxiety disorder, however, it will not work for everyone and patients should beware of risks prior to treatment. Abstract. To evaluate the efficacy and tolerability of quetiapine for the treatment of generalized anxiety disorder (GAD), a literature search of the Medline database was conducted from inception to May 2014. To evaluate the efficacy and tolerability of quetiapine for the treatment of generalized anxiety disorder (GAD), a literature search of the Medline database was conducted from inception to May 2014. The search was not restricted by language. Keywords used in the search were quetiapine and generalized anxiety disorder or anxiety. All studies assessing the use of quetiapine as monotherapy or. Neither the immediate-release or XR formulation is indicated for treating anxiety, but quetiapine has been studied as a treatment for several anxiety disorders, including posttraumatic stress disorder, social phobia, obsessive-compulsive disorder, and anxiety secondary to mood disorders. It has been most extensively studied as treatment for generalized anxiety disorder (GAD). Three trials that. User Reviews for Quetiapine to treat Generalized Anxiety Disorder. Also known as: SEROquel, SEROquel XR. The following information is NOT intended to endorse drugs or recommend therapy. Sept. 4, 2008 -- Seroquel XR, an antipsychotic drug approved to treat schizophrenia and bipolar disorder, may ease generalized anxiety disorder, new research shows. Quetiapine monotherapy in acute treatment of generalized anxiety disorder: a systematic review and meta-analysis of randomized controlled trials Narong Maneeton , 1 Benchalak Maneeton , 1 Pakapan Woottiluk , 2 Surinporn Likhitsathian , 1 Sirijit Suttajit , 1 Vudhichai Boonyanaruthee , 1 and Manit Srisurapanont 1 Summary. There is some evidence that quetiapine monotherapy improves the symptoms of generalised anxiety disorder (GAD) compared with placebo, and limited evidence suggests that it is not more effective than antidepressants.